Chronic obstructive pulmonary disease causes progressive loss of skeletal muscle mass and function. It is known that individuals with sarcopenia in chronic obstructive pulmonary disease are at higher risk of adverse clinical outcomes and mortality. Resistance exercise can counteract skeletal muscle dysfunction by increasing muscle protein synthesis, inducing angiogenesis, and enhancing mitochondrial function. Thus, resistance training should be an important component of comprehensive rehabilitation of individuals with chronic obstructive pulmonary disease. Objective. To analyze the scientific literature on the effects of resistance training on lung function, physical performance, skeletal muscle hypertrophy, quality of life, anxiety, depression, and hospitalization in individuals with chronic obstructive pulmonary disease. Materials and methods. A comprehensive literature search was conducted that matched the aim of the study using PubMed/MEDLINE, Cochrane Library, Web of Science, Scopus, and Google Scholar. Query dates were October-November 2024, and query depth was 2001-2024. Results. Resistance training can increase skeletal muscle strength and mass, improve cardiorespiratory fitness, improve lung function, enhance quality of life, increase physical activity, and reduce anxiety in individuals with chronic obstructive pulmonary disease. Conclusions. These studies indicate that resistance training is an important component of pulmonary rehabilitation in patients with COPD, especially for those with severe or low aerobic exercise tolerance.
Autors:
Sverchkov V. V., Bykov E. V., Chipyshev A. V.
Ural State University of Physical Culture, Russia, Chelyabinsk
Keywords:
#Blood flow restriction training
#Chronic obstructive pulmonary disease
#COPD
#Grip strength
#Rehabilitation
#Resistance training
List of literature:
- Attaway, A. Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank / A. Attaway, R. Lopez, N. Welch [et al] // BMC Pulm Med. − 2024 Apr 17. − № 24(1). – P. 186−199.
- Attaway, A. Nocturnal Hypoxemia Is Associated with Sarcopenia in Patients with Chronic Obstructive Pulmonary Disease / A. Attaway, R. Mehra, J. Zein [et al] // Ann Am Thorac Soc. − 2024 Sep. − № 21(9). – P. 1316−1325.
- Baethge, C. SANRA-a scale for the quality assessment of narrative review articles / C. Baethge, S. Goldbeck-Wood, S. Mertens // Res Integr Peer Rev. – 2019 Mar 26. – № 4. – P. 5–15.
- Confalonieri, M. Chronic Obstructive Pulmonary Disease Definition: Is It Time to Incorporate the Concept of Failure of Lung Regeneration? / M. Confalonieri, L. Braga, F. Salton [et al] // Am J Respir Crit Care Med. – 2023 Feb 1. – № 207(3). – P. 366–367.
- Cornelius, T. Clinical guideline highlights for the hospitalist: GOLD COPD update 2024 / T. Cornelius T // J Hosp Med. – 2024 Sep. – № 19(9). – P. 818–820.
- Cui, S. Effects and long-term outcomes of endurance versus resistance training as an adjunct to standard medication in patients with stable COPD: a multicenter randomized trial / S. Cui, H. Ji, L. Li [et al] // BMC Pulm Med. – 2024 Apr 22. – № 24(1). – P. 196–208.
- Ferté, J. Impact of resistance training on the 6-minute walk test in individuals with chronic obstructive pulmonary disease: A systematic review and meta-analysis / J. Ferté, F. Boyer, R. Taiar [et al] // Ann Phys Rehabil Med. – 2022 May. – № 65(3). – P. 101–115.
- GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. – 2020 Oct 17. – № 396(10258). – P. 1204–1222.
- Gómez-Martínez, M. Impact of Body Composition and Sarcopenia on Mortality in Chronic Obstructive Pulmonary Disease Patients / M. Gómez-Martínez, W. Rodríguez-García, D. González-Islas [et al] // J Clin Med. – 2023 Feb 7. – № 12(4). – P. 1321–1334.
- Iepsen, U. A Systematic Review of Resistance Training Versus Endurance Training in COPD / U. Iepsen, K. Jørgensen, T. Ringbaek [et al] // J Cardiopulm Rehabil Prev. – 2015 May-Jun. – № 35(3). – P. 163–172.
- Iepsen, U. A combination of resistance and endurance training increases leg muscle strength in COPD: An evidence-based recommendation based on systematic review with meta-analyses / U. Iepsen, K. Jørgensen, T. Ringbæk [et al] // Chron Respir Dis. – 2015 May. – № 12(2). – P. 132–145.
- Karagiannis, C. The effects of upper limb exercise training on upper limb muscle strength in people with chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials / C. Karagiannis C, C. Savva, V. Korakakis [et al] // Ther Adv Respir Dis. – 2023 Jan-Dec. – № 17. – P. 175–187.
- Kaymaz, D. Relation between upper-limb muscle strength with exercise capacity, quality of life and dyspnea in patients with severe chronic obstructive pulmonary disease / D. Kaymaz, I. Candemir, P. Ergün [et al] // Clin Respir J. – 2018 Mar. – № 12(3). – P. 1257–1263.
- Kohlbrenner, D. Low-load blood flow restriction strength training in patients with COPD: a randomised single-blind pilot study / D. Kohlbrenner, M. Kuhn, A. Manettas [et al] // Thorax. – 2024 Mar 15. – № 79(4). – P. 340–348.
- Lau, C. Effect on muscle strength after blood flow restriction resistance exercise in early in-patient rehabilitation of post-chronic obstructive pulmonary disease acute exacerbation, a single blinded, randomized controlled study / C. Lau, S. Leung, S. Wah [et al] // Chron Respir Dis. – 2023 Jan-Dec. – № 20. – P. 147–161.
- Li, N. Effects of resistance training on exercise capacity in elderly patients with chronic obstructive pulmonary disease: a meta-analysis and systematic review / N. Li, P. Li, Y. Lu [et al] // Aging Clin Exp Res. – 2020 Oct. – № 32(10). – P. 1911–1922.
- Liao, W. Impact of Resistance Training in Subjects With COPD: A Systematic Review and Meta-Analysis / W. Liao, J. Chen, X. Chen [et al] // Respir Care. – 2015 Aug. – № 60(8). – P. 1130–1145.
- Methenitis, S. Type IIx muscle fibers are related to poor body composition, glycemic and lipidemic blood profiles in young females: the protective role of type I and IIa muscle fibers / S. Methenitis, T. Nomikos, T. Mpampoulis [et al] // Eur J Appl Physiol. – 2024 Feb. – № 124(2). – P. 585–594.
- Methenitis, S. Different eccentric-based power training volumes improve glycemic, lipidemic profile and body composition of females in a dose-dependent manner: Associations with muscle fibres composition adaptations / S. Methenitis, T. Nomikos, T. Mpampoulis [et al] // Eur J Sport Sci. – 2023 Feb. – № 23(2). – P. 241–250.
- Oyama, Y. Combined Effect of Early Nutrition Therapy and Rehabilitation for Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Prospective Randomized Controlled Trial / Y. Oyama, H. Tatsumi, H. Takikawa [et al] // Nutrients. – 2024 Mar 5. – № 16(5). – P. 739–752.
- Qiu, P. The association between walking pace and hand grip strength with the risk of chronic obstructive pulmonary disease: a bidirectional Mendelian randomization study / P. Qiu, M. Chen, S. Lv [et al] // BMC Pulm Med. – 2023 Nov 20. – № 23(1). – P. 450–463.
- Sepúlveda-Loyola, W. Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis / W. Sepúlveda-Loyola, C. Osadnik, S. Phu [et al] // J Cachexia Sarcopenia Muscle. – 2020 Oct. – № 11(5). – P. 1164–1176.
- Sonar, M. Comparative Study of Systemic Inflammatory Markers in Clinical Phenotypes of Chronic Obstructive Pulmonary Disease / M. Sonar, B. Jayadeva, B. Shashibhushan // Tanaffos. – 2023 Feb. – № 22(2). – P. 215–220.
- Su, Y. Exploring the relationship between sarcopenia and 11 respiratory diseases: a comprehensive mendelian randomization analysis / Y. Su, Y. Zhang, D. Zhang [et al] // Aging Clin Exp Res. – 2024 Oct 12. – № 36(1). – P. 205–217.
- Tian, X. A Network Meta-Analysis of Aerobic, Resistance, Endurance, and High-Intensity Interval Training to Prioritize Exercise for Stable COPD / X. Tian, F. Liu, F. Li [et al] // Int J Chron Obstruct Pulmon Dis. – 2024 Sep 16. – № 19. – P. 2035–2050.
- Topcuoğlu, C. Comparison of the effects of high and low-moderate load lower limb resistance training on muscle strength and exercise capacity in individuals with COPD: A systematic review and meta-analysis / C. Topcuoğlu, M. Sağlam, N. Yağlı // Heart Lung. – 2024 Mar-Apr. – № 64. – P. 107–116.
- Würtemberger, G. Funktionelle Effekte unterschiedlicher Trainingsformen bei Patienten mit COPD [Functional effects of different training in patients with COPD] / G. Würtemberger, K. Bastian [et al] // Pneumologie. – 2001 Dec. – № 55(12). – P. 553–562.
- Yu, Z. Chronic obstructive pulmonary disease as a risk factor for sarcopenia: A systematic review and meta-analysis / Z. Yu, J. He, Y. Chen [et al] // PLoS One. – 2024 Apr 18. – № 19(4). – P. 300–312.
- Zhang, Z. Effects of different exercise regimens on prognosis of patients with chronic obstructive pulmonary disease: a systematic reviews and meta-analysis / Z. Zhang, Y. Li // Ann Med. – 2024 Dec. – № 56(1). – P. 239–252.
- Zhou, W. Independent effect of the triglyceride-glucose index on all-cause mortality in critically ill patients with chronic obstructive pulmonary disease and asthma: A retrospective cohort study / W. Zhou, X. Song, W. Dong [et al] // Chron Respir Dis. – 2024 Jan-Dec. – № 21. – P. 147–163.
More about the authors:
Vadim V. Sverchkov, Junior Researcher, Research Institute of Olympic Sports, Teacher, Department of Sports Medicine and Physical Rehabilitation, Ural State University of Physical Culture. e-mail: Vadim.Sverchkov@yandex.ru
Evgeny V. Bykov, Dr.Sci. (Med), Professor, Vice-Rector for Research, Head of the Department of Sports Medicine and Physical Rehabilitation, Ural State University of Physical Culture. e-mail: bev58@yandex.ru
Anton V. Chipyshev, Candidate of Biological Sciences, Associate Professor of the Department of Sports Medicine and Physical Rehabilitation, Ural State University of Physical Culture. e-mail: jk_m@bk.ru