The aim of the study is to analyze scientific data on the role of L-carnitine in enhancing athletic performance and recovery efficiency, as well as investigate its mechanisms of action on various aspects of body functioning such as energy metabolism, blood circulation, muscle tissue condition, endocrine regulation, and cardiovascular health maintenance. The article summarizes existing knowledge about the positive effects of L-carnitine on high-level athletes' performance and recovery, emphasizes biological mechanisms underlying these effects, and identifies potential directions for further research. Materials and methods. An analysis was conducted of contemporary scientific data demonstrating the influence of L-carnitine on reducing markers of muscle damage and oxidative stress caused by intense training. Results. Special attention is given to the impact of L-carnitine on myocardial energy metabolism, improved microcirculation, and reduced inflammatory processes, which collectively contribute to more effective cardiovascular system recovery. Information is provided regarding the effect of L-carnitine on the neuroendocrine system, particularly hormonal balance and fatigue reduction, enabling increased athlete readiness for subsequent trainings and competitions. Various forms of L-carnitine (L-carnitine tartrate, acetyl-L-carnitine) are considered along with their specific influences on recovery processes. Conclusion. Based on an analysis of literature data, it is concluded that including L-carnitine in the diet of athletes experiencing heavy physical loads is advisable to optimize recovery processes, reduce overtraining risks, and enhance overall functional preparedness.
Autors:
Zvyagina E. V., Petrushkina N. P.
Keywords:
#athletes
#fatigue
#L-carnitine
#muscle pain
#oxidative stress
#recovery
List of literature:
- Chekman, I. Ispol`zovanie sovremenny`x farmakologicheskix texnologij dlya poiska novy`x e`rgogenny`x sredstv v sporte: e`mpiricheskij analiz i real`ny`j rezul`tat / I. Chekman, L. Gunina // Nauka v olimpijskom sporte. – 2017. – № 1. – S. 75‒81.
- E`nciklopediya lekarstvenny`x preparatov. Vitaminopodobny`e veshhestva // Konsul`tant vracha – e`lektronny`j resurs : sajt. – Rezhim dostupa: [https://consu-med.ru/ehnciklopediya/element/l-karnitin/] (data dostupa 04.04.2025).
- Karlic, H. Supplementation of L-carnitine in athletes: does it make sense? / H. Karlic, A. Lohninger // Nutrition. – 2004. – Vol. 20, N 7-8. – P. 709–715.
- Brass, E. P. Carnitine and sports medicine: use or abuse? / E. P. Brass // Ann. N.-Y. Acad. Sci. – 2004. – Vol. 1033. – P. 67–78.
- Russell, AP. Energy Substrates in Heart Failure: Metabolism and Beyond / AP. Russell, H. Taegtmeyer // Circ Res. – 2010. – Vol. 107, N 10. – P. 1347‒1358. – doi:10.1161/Circresaha.110.228252.
- Platonov, V. N. E`rgogenny`e sredstva v sisteme podgotovki i sorevnovatel`noj deyatel`nosti sportsmenov / V. N. Platonov // Sistema podgotovki sportsmenov v olimpijskom sporte; v 2-x kn. – K.: Olimp. lit-ra, 2016. – Kn. 2. – S.1014–1089.
- Curran, M. W. Acetyl-L-carnitine (ALCAR) to enhance nerve regeneration in carpal tunnel syndrome: study protocol for a randomized, placebo-controlled trial // J. Olson, M. Morhart, D. Sample, K.M. Chan // Trials. – 2016. – Vol. 17, N 1. – P. 200. doi: 10.1186/s13063-016-1324-2.
- Kim, HJ. Role of Carnitine in Obesity and Insulin Resistance / HJ. Kim, SM Jeon, TS Park, YM Cho, KU Lee // Ann Nutr Metab. – 2010. – Vol. 57, Suppl 2. – P. 27‒31. – doi:10.1159/000322538.
- La Guardia, P.G. Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation / P.G. La Guardia, L.C. Alberici, F.G. Ravagnani, R.R. Catharino, A.E. Vercesi // Front. Physiol. – 2013. – N 4. – P. 103–107. doi: 10.3389/fphys.2013.00103.
- Deval, V. Structural basis for the inhibition of lactate dehydrogenase by oxamate / V. Deval, F. Begue, H. Tricoire, A. Ménez, J.F. Brière // Biochemistry. – 2011. – Vol. 50, N 13. – P. 2381–2390. – doi:10.1021/bi101923.
- Rastgoo, S. The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose-response meta-analysis / S. Rastgoo, ST Fateh, M Nikbaf-Shandiz, N Rasaei, Y Aali, M Zamani, F Shiraseb, O Asbaghi // Inflammopharmacology. – 2023. – Vol. 31, N 5. – P. 2173‒2199. – doi: 10.1007/s10787-023-01323-9.
- Al-Dhuayan, IS. Biomedical role of L-carnitine in several organ systems, cellular tissues, and COVID-19 / IS. Al-Dhuayan // Braz J Biol. – 2023. – Vol. 82. – e267633. – doi: 10.1590/1519-6984.267633.
- Mielgo-Ayuso, J. Effect of Acute and Chronic Oral l-Carnitine Supplementation on Exercise Performance Based on the Exercise Intensity: A Systematic Review / J. Mielgo-Ayuso, L. Pietrantonio, A. Viribay, J. Calleja-González, J. González-Bernal, D. Fernández-Lázaro // Nutrients. – 2021. – Vol. 13, N 12. – P. 4359. – doi: 10.3390/nu13124359.
- Jagim, AR. International society of sports nutrition position stand: energy drinks and energy shots / AR. Jagim, PS. Harty, GM. Tinsley, CM. Kerksick, AM. Gonzalez, RB. Kreider, SM. Arent, R. Jager, AE. Smith-Ryan, JR. Stout, BI. Campbell, T. VanDusseldorp, J. Antonio // J Int Soc Sports Nutr. – 2023. – Vol. 20, N 1. – P. 2171314. – doi: 10.1080/15502783.2023.2171314.
- Fathizadeh, H. The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials / H. Fathizadeh, A. Milajerdi, Ž. Reiner, E. Amirani, Z. Asemi, MA. Mansournia, J. Hallajzadeh // J Diabetes Metab Disord. – 2020. – Vol. 19, N 2. – P. 1879–1894. – doi: 10.1007/s40200-020-00627-9.
- Samborowska, E. Twenty-Four Weeks of L-Carnitine Combined with Leucine Supplementation Does Not Increase the Muscle Carnitine Content in Healthy Active Subjects / E. Samborowska, RA. Olek // Ann Nutr Metab. – 2023. – Vol. 79, N 2. – P. 219–227. – doi: 10.1159/000529333.
- Holms, R. The role of L-karnitine in the treatment of myocardial infarction. Result of CEDIM randomize investigation / R. Holms, P.D. Greenbaum, G. Huang. – London, 2010. – 254 p.
- Hasselwander, O. The role of carnitine in energy metabolism during endurance exercise / O. Hasselwander, L. Pénicaud, C. Obled, M.-C. Babot, C. Aussel, M. Arnal // European Journal of Applied Physiology. – 2006. – T. 97. – N 5. – S. 449–458.
- Hosseini, M. Acute Effects of Oral L-Carnitine Supplementation on Resting Blood Pressure in Young Non-Smoker Male Volunteers: A Randomized, Double Blind, Placebo Controlled Trial / M. Hosseini, M. Abdollahi, A. Rahimi Forushani, R. Mehrdad // Iranian Red Crescent Medical Journal. – 2013. – Vol. 15, N 12. – e8440. – doi:10.5812/ircmj.8440.
- Raffaella Effects of L-carnitine on cardiovascular diseases: a review on human studies / Raffaella et al. // Life Sciences. – 2013. – Vol. 92. – N 12. – P. 649–655.
- Heckman, MG. The safety of L-carnitine supplementation in healthy adults and children / MG. Heckman, CL. Sherry, JP. DeLany, JJ. Kehayias, JR. McNeil, EA. Yetley // Critical Reviews in Food Science and Nutrition. – 2011. – Vol. 51, N 6. – P. 484‒496. – doi:10.1080/10408398.2010.484211.
- Melani, L. Propionyl-L-carnitine intravenous infusion improves intermittent claudication in patients with peripheral vascular disease / L. Melani, AM. Malagoni, E. Di Paolo, A. Turco, G. Buzzigoli // Journal of Cardiovascular Pharmacology. – 2001. – Vol. 37, N 5. – P. 532‒537. – doi:10.1097/00005344-200105000-00014.
- Rajasekar, P. Effects of L-carnitine on RBC membrane composition and function in hyperinsulinemic rats / P. Rajasekar, K. Balasaraswathi, C.V. Anuradha // Ital. J. Biochem. – 2007. – Vol. 56, N 1. – P. 53–60.
- Montgomery, A. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease / A. Montgomery, LJ. Thal, R. Amrein // International Clinical Psychopharmacology. – 2003. – Vol. 18, N 2. – P. 61‒71. – doi:10.1097/00004850-200303000-00003.
- Shen, L. L-carnitine’s role in KAATSU training- induced neuromuscular fatigue / L. Shen, J. Li, Y. Chen, Z. Lu, W. Lyu // Biomed Pharmacother. – 2020. – Vol. 125. – P. 109899. – doi: 10.1016/j.biopha.2020.109899.
- Liu, J. L-carnitine and acetyl-L-carnitine protect against neuronal injury in cell culture and animal models of stroke, epilepsy, and neurotrauma / J. Liu, SP. Soltoff, HS. Waagepetersen, U. Sonnewald, ZX. Shi, GA. Perkins // J Neurosci Res. – 2004. – Vol. 77, N 2. – P. 195-206. – doi:10.1002/jnr.20123.
- Zhu, XZ. L-carnitine attenuates glutamate excitotoxicity in rat cerebral cortical neurons / XZ. Zhu, XQ. Li, Z. Pei, A. Funakoshi, H. Takahashi, A. Nunomura // Brain Research Bulletin. – 2004. – Vol. 64, N 1. – P. 55‒60. – doi:10.1016/j.brainresbull.2004.02.003.
- Kashiwaya, Y. Inside the energy factory within our cells / Y. Kashiwaya, MT. King, J. Xie, K. Clarke, RL. Veech // The Medical Scientist. – 2007. – Vol. 44, N 3. – P. 166‒171.
- Barker, J. Postexercise Blood and Muscle Free L-Carnitine and Acetyl-L-Carnitine Changes After Various Protocols / J. Barker, M. Long, J. Ramos, B. Helwig, NR. LeBlanc, M. Amann // Nutrients. – 2019. – Vol. 11, N 11. – doi:10.3390/nu11112588.
- Sanders, DJ. Effects of Acute Aerobic or Anaerobic Exercise on Plasma Free and Acylated Forms of Carnitine / DJ. Sanders, RA. Knaggs, S. Grant, RC. Harris, DWD. West // Nutrients. – 2021. – Vol. 13, N 10. – doi:10.3390/nu13103357.
- Maran, A. Regulation of Carnitine Metabolism Under Conditions of Health and Disease / A. Maran, HE. Mohamed, A. Sharma, FW. Kari, BVN. Dasari // Front Mol Biosci. – 2022. – Vol. 9. – doi:10.3389/fmolb.2022.822157.
- Garibotto, G. L-Carnitine as a Pharmacological Approach to Improve Cardiac Performance / G. Garibotto, R. Russo, F. Sofi, R. Cerio, C. Ceconi, L. Agnoletti // Nutrients. – 2017. – Vol. 9, N 7. – doi:10.3390/nu9070719.
- Stephens, FB. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle / FB. Stephens, D. Constantin-Teodosiu, PL. Greenhaff // J Anat. – 2007. – Vol. 211, N 6. – P. 703–710. – doi:10.1111/j.1469-7580.2007.00761.
- Cribbs, SK. Effect of high fat diet and aerobic training on skeletal muscle triacylglycerol content and expression of genes involved in lipid metabolism / SK. Cribbs, PC. Geiger, DK. Fox, SL. Davis, JJ. Leddy, DR. Pendergast // Lipids Health Dis. – 2010. – Vol. 9. – doi:10.1186/1476-511X-9-67.
- Costello, M. Training Status Determines the Impact of L-Carnitine Supplementation on Skeletal Muscle Carnitine Content and Recovery from Simulated Match Play in Elite Female Soccer Players / M. Costello, MA. Papandreou, W. Zhang, KF. Faull, I. Chenier, KA. Featherstone // Nutrients. – 2017. – Vol. 9, N 9. – doi:10.3390/nu9091022.
- Russell, AP. Energy Substrates in Heart Failure: Metabolism and Beyond / AP. Russell, H. Taegtmeyer // Circ Res. – 2010. – Vol. 107, N 10. – P. 1347‒1358. – doi:10.1161/CIRCRESAHA.110.228252.
- Alhasaniah, AH. l-carnitine: Nutrition, pathology, and health benefits / AH. Alhasaniah // Saudi J Biol Sci. – 2023. – Vol. 30, N 2. – P. 103555. – doi: 10.1016/j.sjbs.2022.103555.
- Jagim, AR. International society of sports nutrition position stand: energy drinks and energy shots / AR. Jagim, PS. Harty, GM. Tinsley, CM. Kerksick, AM. Gonzalez, RB. Kreider, SM. Arent, R. Jager, AE. Smith-Ryan, JR. Stout, BI. Campbell, T. VanDusseldorp, J. Antonio // J Int Soc Sports Nutr. – 2023. – Vol. 20, N 1. – P. 2171314. – doi: 10.1080/15502783.2023.2171314.
More about the authors:
Ekaterina V. Zvyagina – Candidate of Pedagogical Sciences, Associate Professor, Associate Professor of the Department of Physiology, Ural State University of Physical Culture. Chelyabinsk, Russia.
Nadezhda P. Petrushkina – Doctor of Medical Sciences, Head of the Department of Physiology, Ural State University of Physical Culture. Chelyabinsk, Russia.